SSRI Discontinuation Syndrome

SSRI Discontinuation Syndrome (PLEASE NOTE- This article is written by a non-physician for educational purposes only and does not replace consultation with a qualified physician. If you are having any problems after discontinuing your antidepressant seek an immediate medical consult. The information shared on this website neither constitutes nor should be interpreted as the professional medical advice of a physician, pharmacist, or other prescriber of psychiatric medication.)

Many psychotherapy clients combine their depression/anxiety psychotherapy treatment with medication. Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed medications for the treatment of depression and anxiety. Like all drugs, these medications have both therapeutic effects and side (i.e., unwanted) effects. One of the major possible side effects of an SSRI medication isn’t encountered until one tries to discontinue its use.

Discontinuation syndrome is the name given to a side effect that occurs on cessation of certain psychiatric medications. This side effect is often experienced on discontinuation of SSRI variants. Here are some things you should know:

Some Common SSRIs (Brand Names) Prozac, Zoloft, Celexa, Lexapro, Paxil, Viibryd

Non-exhaustive List of Discontinuation Syndrome Symptoms

• Paresthesia (tingling or prickling of your skin), numbness

• Dizziness or coordination problems

• Lethargy and sleep problems

• Disturbing thoughts or dreams

• Nausea, vomiting or diarrhea

• Rebound irritability, anxiety or low mood

• So called “brain zaps” or what feel like brief electric shocks to the brain (for more information, check out this Psychology Today link and/or speak to your doctor)

Does Discontinuation Syndrome Mean I am Addicted? Most doctors consider antidepressants non-addictive. One does not experience a “craving” for an antidepressant although discontinuation symptoms (above) can occur. See this WebMD link for further information.

How Long Will Discontinuation Symptoms Last? Discontinuation symptoms can subside within 1 to 3 weeks but such symptoms may go on much longer for some individuals. If symptoms worsen, it also is possible you are having a depressive or anxiety relapse.

Basics for Mitigating Discontinuation Syndrome Symptoms

• Always discontinue under supervision of a qualified physician.

• Use a slow and gradual tapering process over weeks to months time (tapering requirements vary). The gradual adjustment of your dose is known as titration.

• Don't stop taking your medication abruptly. Most people who experience problems stop taking their medication in this manner.

• Be aware that some people may have problems despite precautions again highlighting the need for physician supervision.